Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyridine → Oleyloxyethyl phosphorylcholine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | (2-Bromoethoxy)phosphonoyl dichloride | HCID 4684632 | — |
| 반응물 | Emulphor | HCID 5364713 | — |
| 반응물 | Chloroform acetone | HCID 15930782 | — |
| 용매 | Benzene | HCID 241 | — |
| 생성물 | Oleyloxyethyl phosphorylcholine | HCID 13116658 | 9% |
반응 단계
In benzene were dissolved 4.0 g of 2-[(Z)-9-octadecen-1-yl)oxyethanol and 4.6 g of 2-bromoethyl phosphorodichloridate, and following dropwise addition of 1.5 g of pyridine under ice-cooling, the mixture was stirred at room temperature. The reaction mixture was treated by the procedure of Production Example 1 including hydrolysis, quaternization, purification by silica gel column chromatography and recrystallization from chloroform-acetone to give 0.52 g (9%) of the desired product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04542219 |
| 출처 데이터셋 | uspto-grants-1985_09 |
| ORD ID | ord-686d7471b1af47a4967c586248a8bbef |
| 출처 메모 | uspto-grants-1985_09 |