(RS)-Naproxen methyl ester → 2-(6-Methoxy-2-naphthyl)propionic acid

HRID 1719809

반응식

HRID 1719809 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[C:8]([CH:13]([CH3:18])[C:14]([O:16]C)=[O:15])[CH:7]=[CH:6]2.CO.[OH-].[K+].O>O>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[C:8]([CH:13]([CH3:18])[C:14]([OH:16])=[O:15])[CH:7]=[CH:6]2

참가 물질

4

반응물 2

HCID 529084(RS)-Naproxen methyl esterHCID 86591755KOH MeOH Water

생성물 1

HCID 13022-(6-Methoxy-2-naphthyl)propionic acid

시약·촉매·용매 1

HCID 962Water용매

실험 절차

The crude methyl 2-(6-methoxy-2-naphthyl)propionate is hydrolyzed with methanol/potassium hydroxide/water until TLC indicates no remaining ester. Then the reaction mixture is poured into water and extracted with methylene chloride and acidified with hydrochloric acid. The mixture is filtered and the organic and aqueous layers are separated. The aqueous layer then is acidified and filtered to yield 13.5 g of 2-(6-methoxy-2-naphthyl)propionic acid (melting point: 153°-155° C.).

후처리

  1. extractionextracted with methylene chloride
  2. filtrationThe mixture is filtered
  3. customthe organic and aqueous layers are separated
  4. filtrationfiltered

출처 및 근거

ORD 기록
ord-2f3d07daeb9a4c1d86d82bc027c3e674
출처 데이터셋
uspto-grants-1985_09
특허 번호
US04542237

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