Dimethylformamide → Dimethyl[[6-(2-ethylbutyramido)-4-quinazolinylamino]methylene]propanedioate

HRID 1719954

반응식

HRID 1719954 반응식
[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([NH:12][C:13](=[O:19])[CH:14]([CH2:17][CH3:18])[CH2:15][CH3:16])[CH:10]=2)[N:5]=[CH:4][N:3]=1.CO[CH:22]=[C:23]([C:28]([O:30][CH3:31])=[O:29])[C:24]([O:26][CH3:27])=[O:25].CN(C)C=O>O>[CH3:27][O:26][C:24](=[O:25])[C:23](=[CH:22][NH:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([NH:12][C:13](=[O:19])[CH:14]([CH2:17][CH3:18])[CH2:15][CH3:16])[CH:10]=2)[N:5]=[CH:4][N:3]=1)[C:28]([O:30][CH3:31])=[O:29]

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 90770Dimethyl methoxymethylenemalonateHCID 130604624-Amino-6-(2-ethylbutyramido)quinazoline

생성물 1

HCID 13060503Dimethyl[[6-(2-ethylbutyramido)-4-quinazolinylamino]methylene]propanedioate수율 56.1%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
100 °C

실험 절차

A mixture of 4-amino-6-(2-ethylbutyramido)-quinazoline (5.58 g), dimethyl methoxymethylenepropanedioate (5.62 g) and N,N-dimethylformamide (22 ml) was stirred at 100° C. for 1.5 hours. After cooling to ambient temperature, water (90 ml) was added to the reaction mixture. The resulting solid was separated by filtration, washed with water and dried to give dimethyl[[6-(2-ethylbutyramido)-4-quinazolinylamino]methylene]propanedioate (4.85 g).

후처리

  1. temperatureAfter cooling to ambient temperature
  2. customThe resulting solid was separated by filtration
  3. washwashed with water
  4. customdried

출처 및 근거

ORD 기록
ord-40395b298bb54901846d5292396fb08b
출처 데이터셋
uspto-grants-1985_09
특허 번호
US04543356

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