참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Dimethyl methoxymethylenemalonate | HCID 90770 | — |
| 반응물 | 4-Amino-6-(2-methylpropionamido)quinazoline | HCID 13060463 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | Dimethyl[[6-(2-methylpropionamido)-4-quinazolinylamino]methylene]propanedioate | HCID 13302083 | 88.8% |
반응 단계
A mixture of 4-amino-6-(2-methylpropionamido)-quinazoline (6.2 g) and dimethyl methoxymethylenepropanedioate (7.01 g) in N,N-dimethylformamide (25 ml) was stirred at 100° C. for 1.5 hours and cooled to room temperature. Water was added to the reaction mixture. The resulting solid was separated by filtration, washed with water and dried to give dimethyl[[6-(2-methylpropionamido)-4-quinazolinylamino]methylene]propanedioate (8.9 g). Recrystallization from ethyl acetate gave pure crystals melting at 212°-214° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04543356 |
|---|
| 출처 데이터셋 | uspto-grants-1985_09 |
|---|
| ORD ID | ord-3ccfa455739949d5abf82c126719b528 |
|---|
| 출처 메모 | uspto-grants-1985_09 |
|---|
