Dimethyl[[6-(3-cyclopentylpropionamido)-4-quinazolinylamino]methylene]propanedioate → methyl 4-oxo-10-(3-cyclopentylpropionamido)-4H-pyrimido[1,2-C]quinazoline-3-carboxylate

HRID 1719960

반응식

HRID 1719960 반응식
[CH3:1][O:2][C:3](=[O:31])[C:4](=[CH:9][NH:10][C:11]1[C:20]2[C:15](=[CH:16][CH:17]=[C:18]([NH:21][C:22](=[O:30])[CH2:23][CH2:24][CH:25]3[CH2:29][CH2:28][CH2:27][CH2:26]3)[CH:19]=2)[N:14]=[CH:13][N:12]=1)[C:5](OC)=[O:6]>C1(OC2C=CC=CC=2)C=CC=CC=1>[O:6]=[C:5]1[N:12]2[CH:13]=[N:14][C:15]3[CH:16]=[CH:17][C:18]([NH:21][C:22](=[O:30])[CH2:23][CH2:24][CH:25]4[CH2:29][CH2:28][CH2:27][CH2:26]4)=[CH:19][C:20]=3[C:11]2=[N:10][CH:9]=[C:4]1[C:3]([O:2][CH3:1])=[O:31]

참가 물질

3

반응물 1

HCID 13060507Dimethyl[[6-(3-cyclopentylpropionamido)-4-quinazolinylamino]methylene]propanedioate

생성물 1

HCID 13060558methyl 4-oxo-10-(3-cyclopentylpropionamido)-4H-pyrimido[1,2-C]quinazoline-3-carboxylate수율 70.5%

시약·촉매·용매 1

HCID 7583Diphenyl Ether용매

반응 조건

온도
255 °C

실험 절차

A mixture of dimethyl[[6-(3-cyclopentylpropionamido)-4-quinazolinylamino]methylene]propanedioate (6.9 g) in diphenyl ether (53 ml) was stirred at 255° C. for 15 minutes and cooled to ambient temperature. The resulting solid was collected, washed with hexane and dried. There was obtained methyl 4-oxo-10-(3-cyclopentylpropionamido)-4H-pyrimido[1,2-C]quinazoline-3-carboxylate (4.5 g).

후처리

  1. temperaturecooled to ambient temperature
  2. customThe resulting solid was collected
  3. washwashed with hexane
  4. customdried

출처 및 근거

ORD 기록
ord-75c201dac2b740bf8d007073cecaba22
출처 데이터셋
uspto-grants-1985_09
특허 번호
US04543356

연결된 노트

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