(2R)-Methyl 5-methoxytetrahydrofuran-2-carboxylate → (2R)-Methyl 5-hydroxytetrahydrofuran-2-carboxylate

반응식

C[O:2][CH:3]1[O:7][C@@H:6]([C:8]([O:10][CH3:11])=[O:9])[CH2:5][CH2:4]1>CO>[OH:2][CH:3]1[O:7][C@@H:6]([C:8]([O:10][CH3:11])=[O:9])[CH2:5][CH2:4]1

참가 물질

실험 절차

Methyl (2R)-Tetrahydro-5-hydroxy-2- furoate was prepared as for the S-isomer from methyl (2R)-tetrahydro-5-methoxy-2-furoate in similar yield: α!D25 -9.2° (c=1.8, CH3OH); IR (neat, cm-1) 3543 (br), 2956, 1741, 1068, 1010; 1H NMR (CDCL3) for diastereomer A (58%) a 5.62 (m, 1H), 4.67 (dd, J=6.5, 8.1 Hz, 1H), 3.78 (s, 3H), 2.46-1.93 (m, 4H); for diastereomer B (42%) δ 5.75 (m, 1H), 4.73 (dd, J=3.8, 8.5 Hz, 1H), 3.76 (s, 3H), 2.46-1.93 (m, 4H); HRMS calculated for C6H10O4 (M+), 146.0579, found 46.0577.

출처 및 근거

ORD 기록: ord-c3b23f25ef984abf994e15671bd9e99d
출처 데이터셋: uspto-grants-1996_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05504107

반응 노트

불러오는 중…

참가 물질

반응물 1

HCID 45089865(2R)-Methyl 5-methoxytetrahydrofuran-2-carboxylate

생성물 1

HCID 45090054(2R)-Methyl 5-hydroxytetrahydrofuran-2-carboxylate

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

출처 및 근거

ORD 기록: ord-c3b23f25ef984abf994e15671bd9e99d
출처 데이터셋: uspto-grants-1996_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05504107

반응 노트

불러오는 중…