Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Terazosin Hydrochloride → Terazosin Hydrochloride Anhydrous
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Terazosin Hydrochloride | HCID 63016 | — |
| 반응물 | 2-Chloro-6,7-dimethoxy-4-quinazolinamine | HCID 90235 | — |
| 반응물 | 1-(Tetrahydro-2-furoyl)piperazine | HCID 2734641 | — |
| 생성물 | Terazosin Hydrochloride Anhydrous | HCID 44383 | — |
반응 단계
In its principal embodiment, the present invention comprises a process for the preparation of 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)piperazine hydrochloride dihydrate comprising the steps of a) reacting 4-amino-2-chloro-6,7-dimethoxyquinazoline with N-(2-tetrahydrofuroyl)-piperazine in an anhydrous polar organic solvent in the absence of an added acid scavenger to produce the Form IV crystalline modification of anhydrous 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)piperazine hydrochloride; and b) thereafter converting the product of Step a) to 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)piperazine hydrochloride dihydrate.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05504207 |
| 출처 데이터셋 | uspto-grants-1996_04 |
| ORD ID | ord-e94674bedc084d458e46f1ba0561a9ad |
| 출처 메모 | uspto-grants-1996_04 |