Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrogen Bromide → 4-Chloroquinolin-6-ol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrogen Bromide | HCID 260 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 4-Chloro-6-methoxyquinoline | HCID 228348 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 4-Chloroquinolin-6-ol | HCID 18433132 | 56.3% |
반응 단계
A solution of 4.99 g (18.1 mmol) of 4-chloro-6-methoxyquinoline and 50 mL of 48% hydrobromic acid is heated under reflux for seven hours. Upon cooling to room temperature, the reaction solution afforded a dark solid that was then slurried in water. The aqueous mixture was adjusted to pH 10 by the addition of 4N sodium hydroxide. The resulting solid was filtered, washed with water and air-dried to give 1.83 g (56%) of 4-chloroquinolin-6-ol: m.p. 223° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05506235 |
| 출처 데이터셋 | uspto-grants-1996_04 |
| ORD ID | ord-c0fdfe9b5da74a6c90547c030d1edfe9 |
| 출처 메모 | uspto-grants-1996_04 |