Water → 1-(2-Anilinoethyl)-4-methoxymethoxypiperidine

HRID 1720296노트

반응식

HRID 1720296 반응식
[NH:1]([C:8]([CH2:10][N:11]1[CH2:16][CH2:15][CH:14]([O:17][CH2:18][O:19][CH3:20])[CH2:13][CH2:12]1)=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-].[OH-].[K+].O>O1CCCC1.C(OCC)(=O)C>[NH:1]([CH2:8][CH2:10][N:11]1[CH2:16][CH2:15][CH:14]([O:17][CH2:18][O:19][CH3:20])[CH2:13][CH2:12]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

7

반응물 4

HCID 962WaterHCID 14797Potassium HydroxideHCID 21226445Aluminium lithium hydrideHCID 229236881-(Anilinocarbonylmethyl)-4-methoxymethoxypiperidine

생성물 1

HCID 229237061-(2-Anilinoethyl)-4-methoxymethoxypiperidine수율 98.6%

시약·촉매·용매 2

HCID 8028Tetrahydrofuran용매2회HCID 8857Ethyl Acetate용매

실험 절차

A solution of 3.64 g of 1-(anilinocarbonylmethyl)-4-methoxymethoxypiperidine in 10 ml of tetrahydrofuran was added to a suspension of 630 mg of lithium aluminum hydride in 50 ml of tetrahydrofuran. The mixture was refluxed for 3 hours. To the reaction mixture were added 1.5 ml of an aqueous solution containing 10% of potassium hydroxide and 1.5 ml of water. The mixture was diluted with ethyl acetate, and the dilution was filtered. The solvent in the filtrate was removed by distillation to obtain 3.41 g of 1-(2-anilinoethyl)-4-methoxymethoxypiperidine.

후처리

  1. temperatureThe mixture was refluxed for 3 hours
  2. filtrationthe dilution was filtered
  3. customThe solvent in the filtrate was removed by distillation

출처 및 근거

ORD 기록
ord-c3ad9d8cfb27477b9f7d01af74960ffe
출처 데이터셋
uspto-grants-1996_04
특허 번호
US05506239

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