Water → omega-Cyclohexyldodecanoic acid

HRID 1720805

반응식

HRID 1720805 반응식
[OH2:1].[CH:2]1([CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][OH:20])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1>S(=O)(=O)(O)O.CC(C)=O>[CH:2]1([CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19]([OH:1])=[O:20])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1

참가 물질

5

반응물 2

HCID 962WaterHCID 1487778512-Cyclohexyldodecanol

생성물 1

HCID 193525omega-Cyclohexyldodecanoic acid수율 58.7%

시약·촉매·용매 2

HCID 180Acetone용매HCID 1118Sulfuric Acid용매

실험 절차

CrO3 (VI) (3.204 g, 32.04 mM) was dissolved in sulfuric acid (2.76 ml), followed by stirring for a time, and then water (4.8 ml) was added to yield a solution. This solution was added drop by drop to a solution of 12-cyclohexyldodecanol (5.36 g, 20 mM) in acetone (300 ml) under ice cooling conditions, followed by stirring for 1 hour. To the mixture, iso-prapanol (about 2 ml) was added and then concentrated to dryness under reduced pressure. To the resulting residue, water (50 ml) and chloroform (50 ml) were added, followed by vigorous stirring, after which the chloroform layer was separated. The chloroform layer was dryed over anhydrous sodium sulfate, purified by silica gel colum (50 g) (methanol-chloroform (1:49)) to yield the title compound (5.3 g, yield 58.7%) as a colorless powder.

후처리

  1. customto yield a solution
  2. stirringby stirring for 1 hour
  3. additionTo the mixture, iso-prapanol (about 2 ml) was added
  4. concentrationconcentrated to dryness under reduced pressure
  5. additionTo the resulting residue, water (50 ml) and chloroform (50 ml) were added
  6. customafter which the chloroform layer was separated
  7. custompurified by silica gel colum (50 g) (methanol-chloroform (1:49))

출처 및 근거

ORD 기록
ord-c215d465787f42319d335885df261e62
출처 데이터셋
uspto-grants-1996_04
특허 번호
US05506267

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