Trifluoroacetic acid → (4-(6,7-Bis(stearyloxy)-4-thiaheptanoylamino)benzoyl)glutamic acid

HRID 1720819노트

반응식

HRID 1720819 반응식
C([O:5][C:6](=[O:73])[C@H:7]([CH2:64][CH2:65][C:66]([O:68]C(C)(C)C)=[O:67])[NH:8][C:9](=[O:63])[C:10]1[CH:15]=[CH:14][C:13]([NH:16][C:17](=[O:62])[CH2:18][CH2:19][S:20][CH2:21][CH:22]([O:43][CH2:44][CH2:45][CH2:46][CH2:47][CH2:48][CH2:49][CH2:50][CH2:51][CH2:52][CH2:53][CH2:54][CH2:55][CH2:56][CH2:57][CH2:58][CH2:59][CH2:60][CH3:61])[CH2:23][O:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH3:42])=[CH:12][CH:11]=1)(C)(C)C.FC(F)(F)C(O)=O>>[CH2:44]([O:43][CH:22]([CH2:23][O:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH3:42])[CH2:21][S:20][CH2:19][CH2:18][C:17]([NH:16][C:13]1[CH:12]=[CH:11][C:10]([C:9]([NH:8][C@H:7]([C:6]([OH:73])=[O:5])[CH2:64][CH2:65][C:66]([OH:68])=[O:67])=[O:63])=[CH:15][CH:14]=1)=[O:62])[CH2:45][CH2:46][CH2:47][CH2:48][CH2:49][CH2:50][CH2:51][CH2:52][CH2:53][CH2:54][CH2:55][CH2:56][CH2:57][CH2:58][CH2:59][CH2:60][CH3:61]

참가 물질

3

반응물 2

HCID 6422Trifluoroacetic acidHCID 53695392(4-(6,7-Bis(stearyloxy)-4-thiaheptanoylamino)benzoyl)glutamic acid di-t-butyl ester

생성물 1

HCID 53849118(4-(6,7-Bis(stearyloxy)-4-thiaheptanoylamino)benzoyl)glutamic acid수율 94%

실험 절차

To (4-(6,7-bis(stearyloxy)-4-thiaheptanoylamino)benzoyl)glutamic acid di-t-butyl ester as obtained in Example 25 (75 mg), trifiuoroacetic acid (5 ml) was added, followed by stirring at room temperature for 24 hours. The mixture was concentrated to yield the title compound (64 mg, yield 94%) as a colorless crystal.

후처리

  1. additionwas added
  2. concentrationThe mixture was concentrated

출처 및 근거

ORD 기록
ord-cb20f8d6a0614b1ab398eb740a8b5431
출처 데이터셋
uspto-grants-1996_04
특허 번호
US05506267

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