Oxalyl chloride → 1,2,3,4-Tetrahydronaphthalene-2-carbonyl chloride
반응식
[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH:2]1[C:11]([OH:13])=O.C(Cl)(=O)C([Cl:17])=O>C1(C)C=CC=CC=1>[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH:2]1[C:11]([Cl:17])=[O:13]참가 물질
4
반응 조건
- 온도
- 50 °C
실험 절차
The suspension of 1,2,3,4-tetrahydro-2-naphthoic acid (500 mg, 2.84 mmol) in 5 ml of toluene was treated with oxalyl chloride (720 mg, 5.675 mmol). The mixture was stirred at 50° C. for 5 hrs. All volatile materials were removed in vacuo and product 1,2,3,4-Tetrahydro-2-naphthoyl chloride was obtained as a colorless oil, which was used for next step reaction without further purification.
후처리
- customAll volatile materials were removed in vacuo
출처 및 근거
- ORD 기록
- ord-8b24b32b0c1740e8afae0c7f0c1cb18a
- 출처 데이터셋
- uspto-grants-1996_04
- 특허 번호
- US05508306
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