Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,1-Dibromoethane → 2-Ethoxycarbonylimino-3-(3-trifluoromethylphenyl)thiazolidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,1-Dibromoethane | HCID 11201 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Ethyl N-{[3-(trifluoromethyl)phenyl]carbamothioyl}carbamate | HCID 971062 | — |
| 용매 | Acetone | HCID 180 | — |
| 생성물 | 2-Ethoxycarbonylimino-3-(3-trifluoromethylphenyl)thiazolidine | HCID 54225833 | 83.1% |
반응 단계
A solution of N-(3-trifluoromethylphenyl)-N'-ethoxycarbonylthiourea (1.8 g), dibromoethane (1.29 g) and anhydrous potassium carbonate (2.6 g) in acetone (20 ml) was refluxed for 5 hours. The solvent was removed by distillation, and the residue was extracted with diethyl ether. The extract was washed with water, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was recrystallized from a mixture of hexane and ethanol to give 1.63 g of 2-ethoxycarbonylimino-3-(3-trifluoromethylphenyl)thiazolidine. m.p., 75.8° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05508415 |
| 출처 데이터셋 | uspto-grants-1996_04 |
| ORD ID | ord-3c6dc74784c848f895598dd8e3f3e02a |
| 출처 메모 | uspto-grants-1996_04 |