Piperazine → HCID 19428552, 화합물

반응식

[C:1]12([NH:11][C:12]3[N:17]=[C:16](Cl)[CH:15]=[C:14]([N:19]4[CH2:23][CH2:22][CH2:21][CH2:20]4)[N:13]=3)[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.[NH:24]1[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]1>>[C:1]12([NH:11][C:12]3[N:17]=[C:16]([N:24]4[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]4)[CH:15]=[C:14]([N:19]4[CH2:23][CH2:22][CH2:21][CH2:20]4)[N:13]=3)[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2

참가 물질

반응물 2

HCID 4837Piperazine

HCID 19428500HCID 19428500, 화합물

생성물 1

HCID 19428552HCID 19428552, 화합물수율 69.7%

실험 절차

2-(1-Adamantylamino)-4-chloro-6-pyrrolidinopyrimidine is reacted with piperazine as described in Example 17 to give the title compound in a yield of 69.7%, m.p.: 160°-164° C.

출처 및 근거

ORD 기록: ord-4ffec178ec5b468f8dcfb69efa1bd8a5
출처 데이터셋: uspto-grants-1996_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05510345

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