Piperazine → HCID 19429145, 화합물

반응식

[CH3:1][C:2]([CH3:18])([CH3:17])[CH2:3][NH:4][C:5]1[N:10]=[C:9](Cl)[CH:8]=[C:7]([N:12]2[CH2:16][CH2:15][CH2:14][CH2:13]2)[N:6]=1.[NH:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1>>[CH3:1][C:2]([CH3:18])([CH3:17])[CH2:3][NH:4][C:5]1[N:10]=[C:9]([N:19]2[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]2)[CH:8]=[C:7]([N:12]2[CH2:16][CH2:15][CH2:14][CH2:13]2)[N:6]=1

참가 물질

반응물 2

HCID 4837Piperazine

HCID 19428538HCID 19428538, 화합물

생성물 1

HCID 19429145HCID 19429145, 화합물수율 76%

실험 절차

The reaction of 2-(2,2-dimethylpropylamino)-4-chloro-6-pyrrolidinopyrimidine with piperazine as described in Example 17 leads to the title compound in a yield of 76%, m.p.: 118°-120° C.

출처 및 근거

ORD 기록: ord-d89bcb59e4504ce89722d3e2d9598907
출처 데이터셋: uspto-grants-1996_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05510345

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