Water → 1-(4-Nitrophenyl)-1H-1,2,4-triazole
반응식
[Na].[NH:2]1[CH:6]=[N:5][CH:4]=[N:3]1.F[C:8]1[CH:13]=[CH:12][C:11]([N+:14]([O-:16])=[O:15])=[CH:10][CH:9]=1.O.C(OCC)(=O)C>CN(C=O)C>[N:2]1([C:8]2[CH:13]=[CH:12][C:11]([N+:14]([O-:16])=[O:15])=[CH:10][CH:9]=2)[CH:6]=[N:5][CH:4]=[N:3]1참가 물질
6
실험 절차
1,2,4-Triazole sodium derivative (90%) (17.74 g, 0.18 mol) and 1-fiuoro-4-nitrobenzene (25 g, 0.18 mol), in DMF, (150 ml) was stirred at room temperature for 4 days. Water (300 ml) and ethyl acetate (500 ml) were added and the mixture extracted. The organic layer was separated, washed with water (3×300 ml), dried (MgSO4) and evaporated to give the desired product (24.8 g); δ (360 MHz, CDCl3)7.92 (2H, d, J=9.1 Hz, Ar--H), 8.17 (1H, s, Ar--H), 8.40 (2H, d, J=9.1 Hz, Ar--H), 8.48 (1H, s, Ar--H).
후처리
- extractionthe mixture extracted
- customThe organic layer was separated
- washwashed with water (3×300 ml)
- dry with materialdried (MgSO4)
- customevaporated
출처 및 근거
- ORD 기록
- ord-dc48afb2483d407788b8aa2c76540e1b
- 출처 데이터셋
- uspto-grants-1996_04
- 특허 번호
- US05510362
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