Water → (1R,2E)-2-hydroxyimino-1,2-diphenylethanol;trans-(1R,2R)-cyclohexane-1,2-diamine

HRID 1721505

반응식

HRID 1721505 반응식
[C@@H:1]1([NH2:8])[CH2:6][CH2:5][CH2:4][CH2:3][C@H:2]1[NH2:7].O.[OH:10][CH:11]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[C:12](=[N:19][OH:20])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>C1C=CC=CC=1>[C@@H:1]1([NH2:8])[CH2:6][CH2:5][CH2:4][CH2:3][C@H:2]1[NH2:7].[OH:10][C@H:11]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)/[C:12](=[N:19]/[OH:20])/[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 9924(+-)-Benzoin oximeHCID 438061,2-Diaminocyclohexane, trans-

생성물 1

HCID 88417869(1R,2E)-2-hydroxyimino-1,2-diphenylethanol;trans-(1R,2R)-cyclohexane-1,2-diamine

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

2.00 g (17.5 mmol) of (1R,2R)-(-)-1,2-cyclohexanediamine of α!D20 =-36.7° (c 4.14, H2O) and 4.00 g (17.6 mmol) of dl-1-hydroxy-2-hydroxyimino-1,2-diphenylethane were added to 10 ml of benzene and then heated and stirred, and the solution was cooled to room temperature. Afterward, the precipitated crystals were collected by filtration and then recrystallized from 30 ml of benzene twice to obtain 2.30 g of (1R,2R)-(-)-1,2-cyclohexanediamine·(R)-(-)-(E)-1-hydroxy-2-hydroxyimino-1,2-diphenylethane. Physical properties of the product are as follows.

후처리

  1. temperatureheated
  2. filtrationAfterward, the precipitated crystals were collected by filtration
  3. customrecrystallized from 30 ml of benzene twice

출처 및 근거

ORD 기록
ord-7ddafd4ef86d43d394d657817c8bf3e6
출처 데이터셋
uspto-grants-1996_04
특허 번호
US05510520

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