1-Chloro-2,4,6-trifluorobenzene → 1,3,5-Trifluorobenzene

HRID 1721515

반응식

HRID 1721515 반응식
Cl[C:2]1[C:7]([F:8])=[CH:6][C:5]([F:9])=[CH:4][C:3]=1[F:10]>[Cu].[Zn].S([O-])([O-])(=O)=O.[Cu+2].[Zn].O>[F:8][C:7]1[CH:2]=[C:3]([F:10])[CH:4]=[C:5]([F:9])[CH:6]=1

참가 물질

6

반응물 1

HCID 27366621-Chloro-2,4,6-trifluorobenzene

생성물 1

HCID 97451,3,5-Trifluorobenzene수율 42%

시약·촉매·용매 4

HCID 23994Zinc촉매HCID 24462Copper Sulfate촉매HCID 10290809Zinc copper couple촉매HCID 962Water용매

반응 조건

온도
330 °C

실험 절차

An autoclave was charged with 6.68 g of 2-chloro-1,3,5-trifluorobenzene, 0.5 g of water and 7.5 g of 3-5% zinc-copper couple (prepared by adding an aqueous solution of copper sulfate to an aqueous dispersion of zinc powder (copper/zinc weight ratio of 3 to 5%), allowing the mixture to stand, filtering out the solid component under reduced pressure, and washing, drying and pulverizing the solid component in a mortar), and the content was heated at 330° C. with high speed stirring for 32 hours. After the reaction, the content was distilled off, and a fraction distilled off at 74° to 77° C. was dried over sodium sulfate to obtain 1,3,5-trifluorobenzene in an amount of 2.19 g (yield 42%).

후처리

  1. customprepared
  2. filtrationfiltering out the solid component under reduced pressure
  3. washwashing
  4. customdrying
  5. customAfter the reaction
  6. distillationthe content was distilled off
  7. distillationa fraction distilled off at 74° to 77° C.
  8. dry with materialwas dried over sodium sulfate

출처 및 근거

ORD 기록
ord-7ab27560425f41dbbe58ca1101c9c981
출처 데이터셋
uspto-grants-1996_04
특허 번호
US05510533

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