Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N-Methylephedrine → Metamfepramone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N-Methylephedrine | HCID 4374 | — |
| 반응물 | Trifluoroacetic acid | HCID 6422 | — |
| 반응물 | 2-Iodoxybenzoic acid | HCID 108794 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 용매 | Sodium Bicarbonate | HCID 516892 | — |
| 생성물 | Metamfepramone | HCID 71872 | 90.7% |
반응 단계
N-Methylephedrine (200 mg; 1.12 mmol) was added to a solution of o-iodoxybenzoic acid I (1.56 g, 5.59 mmol) and trifluoroacetic acid (0.13 ml) in DMSO (12 ml). After 8 hours the solution was diluted with NaHCO3 (2.5%, 30 ml) and extracted with ethyl acetate (3×10 ml). The combined organic layers were washed with water (2×5 ml), dried over sodium sulfate and evaporated to dryness under vacuum to give 180 mg (90%) of 2-dimethylamino-1-phenyl-propan-1-one identical to the sample obtained in Example 31.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05510538 |
| 출처 데이터셋 | uspto-grants-1996_04 |
| ORD ID | ord-e1d12438905c4b90822c0531f7a304da |
| 출처 메모 | uspto-grants-1996_04 |