Potassium Carbonate → Ethyl-2-(2-propylimidazol-1-yl)propanoate

HRID 1721885노트

반응식

HRID 1721885 반응식
[CH2:1]([C:4]1[NH:5][CH:6]=[CH:7][N:8]=1)[CH2:2][CH3:3].Br[CH:10]([CH3:16])[C:11]([O:13][CH2:14][CH3:15])=[O:12].C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[CH2:14]([O:13][C:11](=[O:12])[CH:10]([N:5]1[CH:6]=[CH:7][N:8]=[C:4]1[CH2:1][CH2:2][CH3:3])[CH3:16])[CH3:15]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 79040Ethyl 2-bromopropionateHCID 1626172-Propylimidazole

생성물 1

HCID 20070368Ethyl-2-(2-propylimidazol-1-yl)propanoate

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

2-Propylimidazole (5.5 g), ethyl 2-bromopropionate (9.95 g) and potassium carbonate (12.4 g) were stirred in refluxing acetonitrile (100 ml) for 72 hours. The suspension was allowed to cool, filtered and the solvent removed under reduced pressure, yielding the title compound as an off-white foam, 9.2 g [88%].

후처리

  1. temperatureto cool
  2. filtrationfiltered
  3. customthe solvent removed under reduced pressure

출처 및 근거

ORD 기록
ord-2bd3e86144384b45b2db53708bb5d401
출처 데이터셋
uspto-grants-1989_08
특허 번호
US04853392

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