Ethyl bromoacetate → HCID 14622775, 화합물

HRID 1721924노트

반응식

HRID 1721924 반응식
[Cl:1][C:2]1[C:7]([Cl:8])=[C:6]([C:9]([C:11]2[N:15]([CH2:16][O:17][CH2:18][CH3:19])[N:14]=[CH:13][CH:12]=2)=[O:10])[CH:5]=[CH:4][C:3]=1[OH:20].Br[CH2:22][C:23]([O:25][CH2:26][CH3:27])=[O:24].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[Cl:1][C:2]1[C:7]([Cl:8])=[C:6]([C:9]([C:11]2[N:15]([CH2:16][O:17][CH2:18][CH3:19])[N:14]=[CH:13][CH:12]=2)=[O:10])[CH:5]=[CH:4][C:3]=1[O:20][CH2:22][C:23]([O:25][CH2:26][CH3:27])=[O:24]

참가 물질

5

반응물 3

HCID 7748Ethyl bromoacetateHCID 11430Potassium CarbonateHCID 14622774HCID 14622774, 화합물

생성물 1

HCID 14622775HCID 14622775, 화합물수율 88.9%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

1.67 g of 2,3-dichloro-4-(1-ethoxymethyl-5-pyrazolylcarbonyl)phenol, 1.15 g of ethyl bromoacetate and 1.68 g of potassium carbonate are added to 60 ml of acetone, and the mixture is refluxed for 1 hour. The reaction mixture is filtered and the filtrate is evaporated to remove solvent. The residue is dissolved in benzene, and the solution is treated with activated charcoal and evaporated to give an oil, which is then crystallized from isopropyl ether to give 1.89 g of ethyl [2,3-dichloro-4-(1-ethoxymethyl-5-pyrazolylcarbonyl)phenoxy]acetate.

후처리

  1. temperaturethe mixture is refluxed for 1 hour
  2. filtrationThe reaction mixture is filtered
  3. customthe filtrate is evaporated
  4. customto remove solvent
  5. dissolutionThe residue is dissolved in benzene
  6. additionthe solution is treated with activated charcoal
  7. customevaporated
  8. customto give an oil, which
  9. customis then crystallized from isopropyl ether

출처 및 근거

ORD 기록
ord-f2e4782b83334544bc4e8e6c0d8615b9
출처 데이터셋
uspto-grants-1989_08
특허 번호
US04853404

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