alpha-(1-Ethoxymethyl-5-pyrazolyl)-2,3-dichloro-4-ethoxycarbonylmethoxybenzylalcohol → HCID 14622775, 화합물

HRID 1721928노트

반응식

HRID 1721928 반응식
[CH2:1]([O:3][CH2:4][N:5]1[C:9]([CH:10]([OH:26])[C:11]2[CH:16]=[CH:15][C:14]([O:17][CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])=[C:13]([Cl:24])[C:12]=2[Cl:25])=[CH:8][CH:7]=[N:6]1)[CH3:2]>C(Cl)Cl.[O-2].[O-2].[Mn+4]>[Cl:24][C:13]1[C:12]([Cl:25])=[C:11]([C:10]([C:9]2[N:5]([CH2:4][O:3][CH2:1][CH3:2])[N:6]=[CH:7][CH:8]=2)=[O:26])[CH:16]=[CH:15][C:14]=1[O:17][CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20]

참가 물질

4

반응물 1

HCID 20030167alpha-(1-Ethoxymethyl-5-pyrazolyl)-2,3-dichloro-4-ethoxycarbonylmethoxybenzylalcohol

생성물 1

HCID 14622775HCID 14622775, 화합물수율 91.8%

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 6344Dichloromethane용매

실험 절차

770 mg of α-(1-ethoxymethyl-5-pyrazolyl)-2,3-dichloro-4-ethoxycarbonylmethoxybenzylalcohol and 1.66 g of manganese dioxide are suspended in 30 ml of methylene chloride, and the suspension is stirred at room temperature for 24 hours. The reaction mixture is filtered and the filtrate is evaporated to remove solvent. The residue is triturated with a mixture of isopropyl ether and hexane to give 703 mg of ethyl [2,3-dichloro-4-(1-ethoxymethyl-5-pyrazolylcarbonyl)phenoxy]acetate as crystals.

후처리

  1. filtrationThe reaction mixture is filtered
  2. customthe filtrate is evaporated
  3. customto remove solvent
  4. customThe residue is triturated with a mixture of isopropyl ether and hexane

출처 및 근거

ORD 기록
ord-23b98d0e30544857bf6ad14b79aa5454
출처 데이터셋
uspto-grants-1989_08
특허 번호
US04853404

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