HCID 15631682, 화합물 → HCID 14622782, 화합물

HRID 1721934노트

반응식

HRID 1721934 반응식
O.O.O.[Br:4]([O-])=O.[Na+].[Cl:8][C:9]1[C:21]([Cl:22])=[C:20]([C:23]([C:25]2[N:29]([CH2:30][CH3:31])[N:28]=[CH:27][CH:26]=2)=[O:24])[CH:19]=[CH:18][C:10]=1[O:11][CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14]>O>[Cl:8][C:9]1[C:21]([Cl:22])=[C:20]([C:23]([C:25]2[N:29]([CH2:30][CH3:31])[N:28]=[CH:27][C:26]=2[Br:4])=[O:24])[CH:19]=[CH:18][C:10]=1[O:11][CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14]

참가 물질

4

반응물 2

HCID 15631682HCID 15631682, 화합물HCID 86743274HCID 86743274, 화합물

생성물 1

HCID 14622782HCID 14622782, 화합물수율 88.3%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A solution of 1.88 g of sodium bromite trihydrate in 5 ml of water is added dropwise at room temperature to a solution of 1.85 g of ethyl [2,3-dichloro-4-(1-ethyl-5-pyrazolylcarbonyl)phenoxy]acetate and the mixture is stirred at room temperature for 15 hours. The reaction mixture is evaporated to remove solvent and the residue is dissolved in 20 ml of water. The aqueous solution is made alkaline with a saturated sodium bicarbonate solution and extracted with ethyl acetate. The extract is washed with water, dried and evaporated to remove solvent. The residue is crystallized with a mixture of isopropyl ether and hexane to give 1.98 g of ethyl [2,3-dichloro-4-(4-bromo-1-ethyl-5-pyrazolylcarbonyl)phenoxy]acetate.

후처리

  1. customThe reaction mixture is evaporated
  2. customto remove solvent
  3. dissolutionthe residue is dissolved in 20 ml of water
  4. extractionextracted with ethyl acetate
  5. washThe extract is washed with water
  6. customdried
  7. customevaporated
  8. customto remove solvent
  9. customThe residue is crystallized with a mixture of isopropyl ether and hexane

출처 및 근거

ORD 기록
ord-6892f7e8dc684123898c8e161250dd5f
출처 데이터셋
uspto-grants-1989_08
특허 번호
US04853404

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