alpha-(1-Ethoxymethyl-5-pyrazolyl)-2,3-dichloro-4-methoxy-benzylalcohol → HCID 14622785, 화합물

HRID 1721936노트

반응식

HRID 1721936 반응식
[CH2:1]([O:3][CH2:4][N:5]1[C:9]([CH:10]([OH:21])[C:11]2[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[C:13]([Cl:19])[C:12]=2[Cl:20])=[CH:8][CH:7]=[N:6]1)[CH3:2]>C(Cl)Cl.[O-2].[O-2].[Mn+4]>[Cl:20][C:12]1[C:13]([Cl:19])=[C:14]([O:17][CH3:18])[CH:15]=[CH:16][C:11]=1[C:10]([C:9]1[N:5]([CH2:4][O:3][CH2:1][CH3:2])[N:6]=[CH:7][CH:8]=1)=[O:21]

참가 물질

4

반응물 1

HCID 14622784alpha-(1-Ethoxymethyl-5-pyrazolyl)-2,3-dichloro-4-methoxy-benzylalcohol

생성물 1

HCID 14622785HCID 14622785, 화합물수율 90%

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 6344Dichloromethane용매

실험 절차

2.72 g of manganese dioxide are added to a solution of 1.04 g of α-(1-ethoxymethyl-5-pyrazolyl)-2,3-dichloro-4-methoxybenzylalcohol in methylene chloride and the mixture is stirred at room temperature for 27 hours. The reaction mixture is filtered and the filtrate is condensed to an oily residue, which is then crystallized from isopropyl ether to give 0.93 g of (2,3-dichloro-4-methoxyphenyl)(1-ethoxymethyl-5-pyrazolyl)methanone.

후처리

  1. filtrationThe reaction mixture is filtered
  2. customcondensed to an oily residue, which
  3. customis then crystallized from isopropyl ether

출처 및 근거

ORD 기록
ord-4c141264c8fb4744bc6d536ffdaf317e
출처 데이터셋
uspto-grants-1989_08
특허 번호
US04853404

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