Benzaldehyde → 3-(3,4-Dimethoxyphenyl-2-propyl]-5-hydroxymethyl-2-phenyloxazolidine

참여 물질

반응 단계

A mixture of 3-[3-(3,4-dimethoxyphenyl)-2-propylamino]-1,2-propanediol (14.3 g, 0.053 m), benzaldehyde (12.7 g, 0.12 m) and benzoic acid (0.3 g) in toluene (45 ml) is refluxed for 3 hours, collecting the water formed in a Dean-Stark trap. After washing with saturated NaHCO3 solution and with H2O (2x), the solvent is distilled under reduced pressure. Excess benzaldehyde is distilled at 100° C. at 0.1 mm. The residue, (II) (16.88 g, 89%) is used without further purification in the next step.

출처 및 근거