Sodium Carbonate → HCID 178488969, 화합물

HRID 1722019노트

반응식

HRID 1722019 반응식
[C:1]([C:4]1[N:5]=[C:6]([C:9]2[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[CH:11][CH:10]=2)[NH:7][CH:8]=1)(=O)[NH2:2].C([O-])([O-])=O.[Na+].[Na+]>>[C:1]([C:4]1[N:5]=[C:6]([C:9]2[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[CH:11][CH:10]=2)[NH:7][CH:8]=1)#[N:2]

참가 물질

3

반응물 2

HCID 10340Sodium CarbonateHCID 178488972HCID 178488972, 화합물

생성물 1

HCID 178488969HCID 178488969, 화합물수율 71.7%

실험 절차

A mixture of 64 (7.6 g, 0.035 mol) and POC13 (100 ml) was heated at reflux for 5.5 hours. After stirring at room temperature overnight, the suspension was poured into saturated Na2CO3 and the mixture extracted with 20% CH3OH--CHCl3 (3 X). The organic extracts were washed with saturated NaCl, dried, filtered and concentrated to dryness. The residue was chromatographed on silica gel and the product eluted with 5% CH3OH--CHCl3 to yield 5.0 g (71%) of 65; m.p. 219°-20° C. (CH3CN). Analysis calculated for C11H9N3O.

후처리

  1. temperaturewas heated
  2. temperatureat reflux for 5.5 hours
  3. extractionthe mixture extracted with 20% CH3OH
  4. washThe organic extracts were washed with saturated NaCl
  5. customdried
  6. filtrationfiltered
  7. concentrationconcentrated to dryness
  8. customThe residue was chromatographed on silica gel
  9. washthe product eluted with 5% CH3OH

출처 및 근거

ORD 기록
ord-95e15846bb3349168ac4b80e3b7b253a
출처 데이터셋
uspto-grants-1989_08
특허 번호
US04853383

반응 노트

불러오는 중…