Benzaldehyde → [2-Phenyl-3-(4-phenylbutan-2-yl)-1,3-oxazolidin-5-yl]methanol

HRID 1722026노트

반응식

HRID 1722026 반응식
[C:1]1([CH2:7][CH2:8][CH:9]([NH:11][CH2:12][CH:13]([OH:16])[CH2:14][OH:15])[CH3:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH:17](=O)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.C(O)(=O)C1C=CC=CC=1>C1(C)C=CC=CC=1>[C:18]1([CH:17]2[N:11]([CH:9]([CH3:10])[CH2:8][CH2:7][C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)[CH2:12][CH:13]([CH2:14][OH:15])[O:16]2)[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

참가 물질

5

반응물 3

HCID 240BenzaldehydeHCID 243Benzoic AcidHCID 51955603-(1-Phenyl-3-butyl)amino-1,2-propanediol

생성물 1

HCID 53876813[2-Phenyl-3-(4-phenylbutan-2-yl)-1,3-oxazolidin-5-yl]methanol수율 100%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A solution of 94 (24 g, 0.108 mol), toluene, benzaldehyde (40 ml) and benzoic acid (0.5 g) was heated at reflux with a Dean-Stark trap. After 1 hour, the theoretical amount of H2O was collected, the reaction cooled to room temperature and saturated Na2CO3 added. The aqueous layer was separated and washed with CHCl3 (3X). The combined extracts were dried, filtered and concentrated to dryness to yield 34 g (100%) of 95.

후처리

  1. temperatureat reflux with a Dean-Stark trap
  2. customthe theoretical amount of H2O was collected
  3. additionsaturated Na2CO3 added
  4. customThe aqueous layer was separated
  5. washwashed with CHCl3 (3X)
  6. customThe combined extracts were dried
  7. filtrationfiltered
  8. concentrationconcentrated to dryness

출처 및 근거

ORD 기록
ord-e6ffced05b2046e69b4f02e0ca263b05
출처 데이터셋
uspto-grants-1989_08
특허 번호
US04853383

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