Thionyl Chloride → 2,3,5,6-Tetrafluorobenzoyl Chloride

HRID 1722033

반응식

HRID 1722033 반응식
[F:1][C:2]1[C:10]([F:11])=[CH:9][C:8]([F:12])=[C:7]([F:13])[C:3]=1[C:4](O)=[O:5].S(Cl)([Cl:16])=O>>[Cl:16][C:4]([C:3]1[C:2]([F:1])=[C:10]([F:11])[CH:9]=[C:8]([F:12])[C:7]=1[F:13])=[O:5]

참가 물질

3

반응물 2

HCID 24386Thionyl Chloride2회HCID 5675332,3,5,6-Tetrafluorobenzoic Acid

생성물 1

HCID 27340282,3,5,6-Tetrafluorobenzoyl Chloride

실험 절차

A mixture of 2,3,5,6-tetrafluorobenzoic acid (25 g) and thionyl chloride (40 cm3) was heated at the reflux temperature for 3 hours after which the excess thionyl chloride was removed by evaporation under reduced pressure to leave a residue of 1-chlorocarbonyl-2,3,5,6-tetrafluorobenzene. To this was added an excess of dry methanol and the mixture stirred for one hour at the ambient temperature. Removal of excess methanol by evaporation under reduced pressure gave methyl 2,3,5,6-tetrafluorobenzoate (19 g) as a mobile liquid.

후처리

  1. customwas removed by evaporation under reduced pressure

출처 및 근거

ORD 기록
ord-d2fa710f386d43c3b0960f8f8fe28e5f
출처 데이터셋
uspto-grants-1989_08
특허 번호
US04853414

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