Potassium Hydroxide → HCID 23049308, 화합물

HRID 1722219노트

반응식

HRID 1722219 반응식
[C:1]1([C:7]#[C:8][CH2:9][CH2:10]/[CH:11]=[CH:12]/[C:13]([O:15]CC)=[O:14])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[K+]>CO.O>[C:1]1([C:7]#[C:8][CH2:9][CH2:10]/[CH:11]=[CH:12]/[C:13]([OH:15])=[O:14])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

5

반응물 2

HCID 14797Potassium HydroxideHCID 10656958HCID 10656958, 화합물

생성물 1

HCID 23049308HCID 23049308, 화합물수율 91.2%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매2회

반응 조건

온도
50 °C

실험 절차

To a solution of ethyl 7-phenylhept-2E-en-6-ynoate (2.5 g) in methanol was added KOH (2.6 g) in water (6 ml). The mixture was stirred at 50° C. under a nitrogen atmosphere for 40 minutes, cooled, diluted with water (20 ml) and washed with ether (15 ml). The aqueous layer was acidified with 10% HCl and extracted with ether. The ether extracts were combined and dried over MgSO4, and the solvent was distilled off (adding dry benzene (4 ml) to form azeotrope with traces of water) to give 7-phenylhept-2E-en-6-ynoic acid (2 g) as a colourless oily solid.

후처리

  1. temperaturecooled
  2. washwashed with ether (15 ml)
  3. extractionextracted with ether
  4. dry with materialdried over MgSO4
  5. distillationthe solvent was distilled off
  6. addition(adding dry benzene (4 ml) to form azeotrope with traces of water)

출처 및 근거

ORD 기록
ord-025e0a7adfa04361ba9862272893340c
출처 데이터셋
uspto-grants-1989_08
특허 번호
US04855086

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