(Triphenylphosphoranylidene)acetaldehyde → HCID 15596448, 화합물

HRID 1722223노트

반응식

HRID 1722223 반응식
[C:1]1([C:7]#[C:8][CH2:9][CH2:10][CH:11]=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH:13]([CH:15]=P(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)=[O:14]>C(Cl)Cl>[C:1]1([C:7]#[C:8][CH2:9][CH2:10]/[CH:11]=[CH:15]/[CH:13]=[O:14])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

4

반응물 2

HCID 75051(Triphenylphosphoranylidene)acetaldehydeHCID 112406334-Pentynal, 5-phenyl-

생성물 1

HCID 15596448HCID 15596448, 화합물수율 42.9%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

5-Phenylpent-4-ynal (0.5 g) in CH2Cl2 (5 ml) was added to a solution of formylmethylenetriphenyl phosphorane (1.8 g) in CH2Cl2 (10 ml) and the mixture was stirred at room temperature under a dry nitrogen atmosphere for 24 hours. The solvent was removed under reduced pressure and the residue was slurried with ether (50 m), filtered, and the residue washed with ether. The ethereal solutions were combined and the product was purified by chromatography on silica eluting with ether:hexane (1:9) to yield 7-phenylhept-2E-en-6-ynal (0.25 g) as a yellow oil.

후처리

  1. customThe solvent was removed under reduced pressure
  2. filtrationfiltered
  3. washthe residue washed with ether
  4. customthe product was purified by chromatography on silica eluting with ether:hexane (1:9)

출처 및 근거

ORD 기록
ord-868cb69a6d254feab5b398f27565b9ce
출처 데이터셋
uspto-grants-1989_08
특허 번호
US04855086

반응 노트

불러오는 중…