Water → 3-Ethyl-2,4,5-trifluoro-nitrobenzene

HRID 1722300노트

반응식

HRID 1722300 반응식
[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[C:4]([F:9])[C:3]=1[CH2:10][CH3:11].[N+:12]([O-])([O-:14])=[O:13].[K+].O>S(=O)(=O)(O)O>[CH2:10]([C:3]1[C:4]([F:9])=[C:5]([N+:12]([O-:14])=[O:13])[CH:6]=[C:7]([F:8])[C:2]=1[F:1])[CH3:11]

참가 물질

5

반응물 3

HCID 962WaterHCID 24434Potassium NitrateHCID 148346762,3,6-Trifluoro-1-ethylbenzene

생성물 1

HCID 148346773-Ethyl-2,4,5-trifluoro-nitrobenzene수율 81.6%

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매2회

실험 절차

2,3,6-Trifluoro-1-ethylbenzene (1.09 g) is dissolved in conc. sulfuric acid (5.5 ml), and thereto is added with stirring a mixture of potassium nitrate (0.83 g) in conc. sulfuric acid (4 ml) at room temperature, and the mixture is stirred at the same temperature for one hour. The reaction mixture is poured into cold water (100 ml) and is extracted with diethyl ether. The ether layer is washed with aqueous saturated sodium chloride and dried over magnesium sulfate and then concentrated under reduced pressure to give 3-ethyl-2,4,5-trifluoro-nitrobenzene (1.14 g), as yellow oil.

후처리

  1. additionis added
  2. stirringthe mixture is stirred at the same temperature for one hour
  3. extractionis extracted with diethyl ether
  4. washThe ether layer is washed with aqueous saturated sodium chloride
  5. dry with materialdried over magnesium sulfate
  6. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-be8369021ff946aaa140e07e2458d587
출처 데이터셋
uspto-grants-1989_08
특허 번호
US04855292

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