Imidazole → (5-Chloro-1-pentyloxy)(2,2-dimethylethyl)dimethylsilane

HRID 1722366노트

반응식

HRID 1722366 반응식
[Cl:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][OH:7].[Si:8](Cl)([C:11](C)(C)C)([CH3:10])[CH3:9].[CH3:16]N(C)C=O.N1[CH:25]=[CH:24]N=C1>O>[Cl:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][O:7][Si:8]([CH2:11][CH:24]([CH3:25])[CH3:16])([CH3:10])[CH3:9]

참가 물질

6

반응물 4

HCID 795ImidazoleHCID 6228DimethylformamideHCID 28928tert-Butyldimethylsilyl chlorideHCID 789155-Chloro-1-pentanol

생성물 1

HCID 20028701(5-Chloro-1-pentyloxy)(2,2-dimethylethyl)dimethylsilane

시약·촉매·용매 1

HCID 962Water용매

실험 절차

5-Chloropentanol (325 g, 2.65 moles) is added to a solution containing tert-butyldimethylsilyl chloride (439 g, 2.91 moles) and dimethylformamide (1.625 liters). The solution is stirred and imidazole (199 g, 2.91 moles) is added at once. The solution is stirred at room temperature for 6 hours, after which time water (1 liter) is added and the reaction is partitioned with hexanes. The organic phase is separated and the solvent volume reduced under vacuum. The residue is dried over anhydrous magnesium sulfate and the remaining solvent removed under vacuum, leaving a clear, colorless oil. The crude product is subsequently fractionally distilled under reduced pressure leaving the product as a clear, colorless oil (534 g, 2.26 moles), BP 71° C./0.3 mm.

후처리

  1. stirringThe solution is stirred at room temperature for 6 hours
  2. customthe reaction is partitioned with hexanes
  3. customThe organic phase is separated
  4. dry with materialThe residue is dried over anhydrous magnesium sulfate
  5. customthe remaining solvent removed under vacuum
  6. customleaving a clear, colorless oil
  7. distillationThe crude product is subsequently fractionally distilled under reduced pressure

출처 및 근거

ORD 기록
ord-ec93d5375f7b4828b6fa9483421a2b2a
출처 데이터셋
uspto-grants-1989_08
특허 번호
US04855322

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