Potassium Hydroxide → HCID 14180954, 화합물
반응식
[CH3:1][S:2]([NH:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][C:14]([O:16]CC)=[O:15])=[CH:9][CH:8]=1)(=[O:4])=[O:3].[OH-].[K+]>C(O)C.O>[CH3:1][S:2]([NH:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][C:14]([OH:16])=[O:15])=[CH:9][CH:8]=1)(=[O:4])=[O:3]참가 물질
5
실험 절차
A solution of ethyl 4-[[(methylsulphonyl)amino]methyl]benzeneacetate (3.1 g) and 1M KOH (22 ml) in ethanol (50 ml) was stirred at room temperature for 3 h and evaporated in vacuo to leave an off-white solid. This solid was dissolved in water (50 ml) and washed with EA (2×50 ml). The organic extract was discarded and the aqueous layer was acidified (pH1) with 5M hydrochloric acid (about 10 ml) to precipitate the title compound (2.54 g) as a white solid m.p. 167°-169°.
후처리
- customevaporated in vacuo
- customto leave an off-white solid
- washwashed with EA (2×50 ml)
- extractionThe organic extract
- customto precipitate the title compound (2.54 g) as a white solid m.p. 167°-169°
출처 및 근거
- ORD 기록
- ord-9b4030efb73046d4954e2a145c2a3cae
- 출처 데이터셋
- uspto-grants-1989_08
- 특허 번호
- US04855314
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