Retinoyl beta-glucuronide → Glucuronic Acid

HRID 1722490

반응식

HRID 1722490 반응식
CC1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C([O:20][C@@H:21]1[O:26][C@H:25]([C:27]([OH:29])=[O:28])[C@@H:24]([OH:30])[C@H:23]([OH:31])[C@H:22]1[OH:32])=O.CC1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C(F)=O>>[O:20]=[CH:21][C@@H:22]([C@H:23]([C@@H:24]([C@@H:25]([C:27]([OH:29])=[O:28])[OH:26])[OH:30])[OH:31])[OH:32]

참가 물질

3

반응물 2

HCID 5281877Retinoyl beta-glucuronideHCID 5378594(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoyl fluoride

생성물 1

HCID 65041Glucuronic Acid

실험 절차

The first chemical synthesis of retinoyl β-glucuronide was reported by us (Barua & Olson, J. Lipid Res. 26: 1277-1282, 1985), and involves a two-step procedure. Retinoyl fluoride was allowed first to react with 6,3-glucuronolactone to produce the 6,3-lactone of retinoyl glucuronic acid, which was then hydrolysed with very dilute alkali to give retinoyl β-glucuronide. The present invention is an improvement over the two-step procedure.

출처 및 근거

ORD 기록
ord-783443e65d52400c99d916c2b1b555e8
출처 데이터셋
uspto-grants-1989_08
특허 번호
US04855463

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