Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → Retinoyl beta-glucuronide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Glucuronic Acid | HCID 65041 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoyl fluoride | HCID 5378594 | — |
| 용매 | Propan-2-one--water (1/1) | HCID 18366337 | — |
| 생성물 | Retinoyl beta-glucuronide | HCID 5281877 | — |
반응 단계
Retinoyl fluoride can be mixed with commercially available glucuronic acid. The reaction is carried out in acetone/water to facilitate the solubility of the water-insoluble retinoyl fluoride and the water-soluble glucuronic acid. The reaction takes place in slightly alkaline pH and hence sodium bicarbonate is used in the reaction mixture. Stirring the mixture at room temperature for 20-24 hours followed by acidification of the solution and extraction with ethyl acetate yields retinoyl glucuronide as the major product. Pure all-trans retinoyl β-glucuronide can be obtained by a combination of column and high-performance liquid chromatography (HPLC).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04855463 |
| 출처 데이터셋 | uspto-grants-1989_08 |
| ORD ID | ord-6187d176f8dd41d0a6a3ec766ba6771b |
| 출처 메모 | uspto-grants-1989_08 |