Water → 1-Bromo-5-nitroisoquinoline
반응식
[Br:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][N:3]=1.[N+:12]([O-])([O-:14])=[O:13].[K+].O.C([O-])(O)=O.[Na+]>OS(O)(=O)=O.CCOC(C)=O>[Br:1][C:2]1[C:11]2[C:6](=[C:7]([N+:12]([O-:14])=[O:13])[CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][N:3]=1참가 물질
7
실험 절차
The starting material was prepared by reactio of 1-bromoisoquinoline in concentrated H2SO4 at 0° with KNO3. The reaction mixture was worked up with water, NaHCO3 and EtOAc to give 1-bromo-5-nitro isoquinoline, m.p. 187°-8°. Reaction of this compound with trimethyloxonium tetrafluoroborate in CH2Cl2 gave impure 1-bromo-2-methyl-5-nitroisoquinolinium tetrafluoroborate which was used as such. n.m.r. in solvent A:-3.5(s, 3H); 7.7-8.7(m, 5H).
출처 및 근거
- ORD 기록
- ord-e92c7e54245c484898568b3d1d94b3d3
- 출처 데이터셋
- uspto-grants-1989_08
- 특허 번호
- US04855420
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