Formaldehyde → (2S)-2-[benzyl(methyl)amino]propanoic acid

HRID 1722618노트

반응식

HRID 1722618 반응식
[CH2:1]([NH:8][C@H:9]([C:11]([OH:13])=[O:12])[CH3:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:14]=O>C(O)=O>[CH3:14][N:8]([CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[C@H:9]([C:11]([OH:13])=[O:12])[CH3:10]

참가 물질

4

반응물 2

HCID 712FormaldehydeHCID 723764N-benzyl-L-alanine

생성물 1

HCID 825998(2S)-2-[benzyl(methyl)amino]propanoic acid

시약·촉매·용매 1

HCID 284Formic Acid용매

실험 절차

The N-benzylalanine (1), (67 g, 0.374 mole) was taken up in formic acid (41 mL, 88%) and formaldehyde (37 mL, 38%) added. The resulting solution was heated on a steam bath for 11/2 hours. After this period the clear solution was cooled and as much of the solvent as possible removed under reduced pressure. Removal of the water was aided by co-evaporation with methanol. To the residual oil was added methanol (200 mL) and the solution diluted with ether yielding the product as a fine white powder, 63.7 g (88%).

후처리

  1. temperatureThe resulting solution was heated on a steam bath for 11/2 hours
  2. temperatureAfter this period the clear solution was cooled
  3. customas much of the solvent as possible removed under reduced pressure
  4. customRemoval of the water
  5. additionTo the residual oil was added methanol (200 mL)
  6. additionthe solution diluted with ether yielding the product as a fine white powder, 63.7 g (88%)

출처 및 근거

ORD 기록
ord-19abd6cebd6646319ae21afeff832679
출처 데이터셋
uspto-grants-1989_08
특허 번호
US04857440

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