Chlorosuccinimide → 7-Chloro-2,3,4,5-tetrahydro-1-benzoxepin-9-carboxylic acid

HRID 1722642노트

반응식

HRID 1722642 반응식
[O:1]1[C:7]2[C:8]([C:12]([OH:14])=[O:13])=[CH:9][CH:10]=[CH:11][C:6]=2[CH2:5][CH2:4][CH2:3][CH2:2]1.[Cl:15]N1C(=O)CCC1=O>CN(C=O)C.C(OCC)(=O)C>[Cl:15][C:10]1[CH:9]=[C:8]([C:12]([OH:14])=[O:13])[C:7]2[O:1][CH2:2][CH2:3][CH2:4][CH2:5][C:6]=2[CH:11]=1

참가 물질

5

반응물 2

HCID 31398ChlorosuccinimideHCID 127011502,3,4,5-Tetrahydro-1-benzoxepin-9-carboxylic acid

생성물 1

HCID 145020977-Chloro-2,3,4,5-tetrahydro-1-benzoxepin-9-carboxylic acid

시약·촉매·용매 2

HCID 6228Dimethylformamide용매HCID 8857Ethyl Acetate용매

실험 절차

To a solution of 1.7 g (8.9 mmol) of 2,3,4,5-tetrahydro-1-benzoxepin-9-carboxylic acid in 5 ml of DMF is added 1.41 g (10.6 mmol) of N-chlorosuccinimide (NCS) in one portion at room temperature. The solution is stirred overnight and then diluted with ethyl acetate and washed with water. The organic layer is then dried (MgSO4), filtered and concentrated to obtain 7-chloro-2,3,4,5-tetrahydro-1-benzoxepin-9-carboxylic acid.

후처리

  1. washwashed with water
  2. dry with materialThe organic layer is then dried (MgSO4)
  3. filtrationfiltered
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-63d070b3c59c4877ac481d5a274b9914
출처 데이터셋
uspto-grants-1989_08
특허 번호
US04857517

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