Borane → 1-(3,5-Difluoro-4-methoxyphenyl)methanamine

HRID 1722717노트

반응식

HRID 1722717 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([F:12])[C:9]=1[O:10][CH3:11])[CH:5]=O.C1C(/C=N/O)=CC=[N+:17](C[N+]2C=CC(/C=N/O)=CC=2)C=1.[Br-].[Br-].B>O1CCCC1>[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([F:12])[C:9]=1[O:10][CH3:11])[CH2:5][NH2:17]

참가 물질

4

반응물 2

HCID 6331BoraneHCID 178493647HCID 178493647, 화합물

생성물 1

HCID 146264691-(3,5-Difluoro-4-methoxyphenyl)methanamine수율 50%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

The reaction of 3,5-difluoro-4-methoxybenzaldehyde methoxime, (7 g, 35 mmole) and 0.98M borane in tetrahydrofuran (46 ml) substantially as described in 1B above produced 3 g, (50%) of the title compound as a clear oil.

출처 및 근거

ORD 기록
ord-b461391a257146d89abd1587774e3651
출처 데이터셋
uspto-grants-1989_08
특허 번호
US04857540

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