Ethanol → HCID 54280119, 화합물
반응식
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([NH2:9])=[S:8])=[CH:5][CH:4]=1.C(O)C.Cl[CH:16]([CH3:20])[C:17](=O)[CH3:18]>CCOCC>[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]2[S:8][C:16]([CH3:20])=[C:17]([CH3:18])[N:9]=2)=[CH:5][CH:4]=1참가 물질
5
실험 절차
To a stirred mixture of 65.1 g (4-methoxy)thiobenzamide and 156 ml ethanol was added dropwise 50.1 g 3-chloro-2-butanone, and the reaction mixture was heated at reflux for 3 hours. An additional 6.1 g 2-chloro-3-butanone was added and heating was continued for an additional hour. The reaction mixture was cooled, 300 ml ether added, and the solid which precipitated was collected and dried to give 74.5 g 2-(4-methoxyphenyl)-4,5-di-methylthiazole in the form of its hydrochloride monohydrate, m.p. 166-170° C.
후처리
- temperaturethe reaction mixture was heated
- temperatureat reflux for 3 hours
- temperatureheating
- waitwas continued for an additional hour
- temperatureThe reaction mixture was cooled
- customthe solid which precipitated
- customwas collected
- customdried
출처 및 근거
- ORD 기록
- ord-a21e6ef65e0d4a5e80e8e52a13fadd73
- 출처 데이터셋
- uspto-grants-1989_08
- 특허 번호
- US04857539
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