4-(2-Methyl-1,3-thiazol-4-yl)phenol → HCID 6483426, 화합물

반응식

[CH3:1][C:2]1[S:3][CH:4]=[C:5]([C:7]2[CH:12]=[CH:11][C:10]([OH:13])=[CH:9][CH:8]=2)[N:6]=1.Br[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][C:22]1[O:26][N:25]=[C:24]([CH3:27])[CH:23]=1>>[CH3:27][C:24]1[CH:23]=[C:22]([CH2:21][CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][O:13][C:10]2[CH:11]=[CH:12][C:7]([C:5]3[N:6]=[C:2]([CH3:1])[S:3][CH:4]=3)=[CH:8][CH:9]=2)[O:26][N:25]=1

참가 물질

반응물 2

HCID 5917434-(2-Methyl-1,3-thiazol-4-yl)phenol

HCID 133169675-(7-Bromoheptyl)-3-methylisoxazole

생성물 1

HCID 6483426HCID 6483426, 화합물

실험 절차

3-Methyl-5-{7-[4-(2-methyl-4-thiazolyl)phenoxy]heptyl}-isoxazole [I; Z=N, Het=4-(2-methyl-4-thiazolyl), R1 and R2 =H, Y=(CH2)7 ] was prepared from 7.3 g of 4-(2-methyl-4-thiazolyl)phenol and 5-(7-bromoheptyl)-3-methylisoxazole according to the procedure of Example 4: yield 10.6 g, m.p. 100-101° C.

출처 및 근거

ORD 기록: ord-71305e9a5af44e6baf5acda33d5a324c
출처 데이터셋: uspto-grants-1989_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04857539

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