3-Isobutyl-1-(4-nitrophenyl)-3-azabicyclo[3.1.1]heptane-2,4-dione → 1-(4-aminophenyl)-3-isobutyl-3-azabicYclo[3.1.1]heptane-2,4-dione

HRID 1722868

반응식

HRID 1722868 반응식
[CH2:1]([N:5]1[C:10](=[O:11])[CH:9]2[CH2:12][C:7]([C:13]3[CH:18]=[CH:17][C:16]([N+:19]([O-])=O)=[CH:15][CH:14]=3)([CH2:8]2)[C:6]1=[O:22])[CH:2]([CH3:4])[CH3:3]>C(O)C.[Pd]>[NH2:19][C:16]1[CH:15]=[CH:14][C:13]([C:7]23[CH2:8][CH:9]([CH2:12]2)[C:10](=[O:11])[N:5]([CH2:1][CH:2]([CH3:3])[CH3:4])[C:6]3=[O:22])=[CH:18][CH:17]=1

참가 물질

4

반응물 1

HCID 148726303-Isobutyl-1-(4-nitrophenyl)-3-azabicyclo[3.1.1]heptane-2,4-dione

생성물 1

HCID 148726351-(4-aminophenyl)-3-isobutyl-3-azabicYclo[3.1.1]heptane-2,4-dione

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

In a manner analogous to that described in Example 1, 2.0 g of 3-isobutyl-1-(4-nitrophenyl)-3-azabicyclo[3.1.1]heptane-2,4-dione in 100 ml of ethanol are hydrogenated in the presence of 0.1 g of palladium-on-carbon and worked up. Melting point 158°-160° (from ethyl acetate/petroleum ether).

출처 및 근거

ORD 기록
ord-bcbe4124bd7e460fae3f7cd7a72d880f
출처 데이터셋
uspto-grants-1989_08
특허 번호
US04857660

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