Hydrogen Peroxide → Methyl 2-chloracetamidoacrylate N-acryloamidomethyl 2-oxopyrrolidine

HRID 1722989노트

반응식

HRID 1722989 반응식
[Cl:1][CH2:2][C:3]([NH:5][C:6](=[CH2:11])[C:7]([O:9][CH3:10])=[O:8])=[O:4].[C:12]([NH:16][CH2:17][N:18]1[CH2:22][CH2:21][CH2:20][C:19]1=[O:23])(=[O:15])[CH:13]=[CH2:14].OO>CO>[Cl:1][CH2:2][C:3]([NH:5][C:6](=[CH2:11])[C:7]([O:9][CH3:10])=[O:8])=[O:4].[C:12]([NH:16][CH2:17][N:18]1[CH2:22][CH2:21][CH2:20][C:19]1=[O:23])(=[O:15])[CH:13]=[CH2:14]

참가 물질

5

반응물 3

HCID 784Hydrogen PeroxideHCID 18414899Acrylamidomethyl 2-oxopyrrolidineHCID 22251401Methyl 2-(2-chloroacetamido)prop-2-enoate

생성물 1

HCID 131716038Methyl 2-chloracetamidoacrylate N-acryloamidomethyl 2-oxopyrrolidine

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
50 °C

실험 절차

93.8 g of methyl 2-chloracetamidoacrylate, 31.2 g of N-acrylamidomethyl-2-oxopyrrolidine, 3.5 l. of methanol and 50 g of a 33% hydrogen peroxide solution are placed in a 4 l. photochemical reactor equipped with a 2000 W type Q 2020 original Hanau-type lamp. The solution is heated to 50° C. and irradiated for 6 hours. The reaction mixture is then filtered and the solution is concentrated to 400 g and poured into 5 l. of ethyl ether. The resulting 93 g of polymer is then dried. The water-soluble fraction is extracted with 1.8 l. of water at 50° C. 68 g of water-soluble polymer are obtained.

후처리

  1. customphotochemical reactor equipped with a 2000 W type Q 2020 original Hanau-type lamp
  2. customirradiated for 6 hours
  3. filtrationThe reaction mixture is then filtered
  4. concentrationthe solution is concentrated to 400 g
  5. additionpoured into 5 l
  6. dry with materialThe resulting 93 g of polymer is then dried
  7. extractionThe water-soluble fraction is extracted with 1.8 l
  8. customat 50° C
  9. custom68 g of water-soluble polymer are obtained

출처 및 근거

ORD 기록
ord-1acde478805541fd9776c6aeb1e4f2d3
출처 데이터셋
uspto-grants-1989_08
특허 번호
US04859460

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