1,2-Diaminocyclohexane, trans- → N-[4-amino-3-(4-amino-3-methoxyphenyl)thieno[3,2-c]pyridin-7-yl]-2-pyrrolidin-1-ylacetamide triacetate salt

https://huagongshe.com/ko/reaction/17231

참여 물질

역할	이름	HCID	투입량
반응물	1,2-Diaminocyclohexane, trans-	HCID 43806	—
반응물	Potassium Phosphate, Tribasic	HCID 62657	—
반응물	1-Pyrrolidineacetamide	HCID 13475825	—
반응물	3-(4-Amino-3-methoxyphenyl)-7-iodothieno[3,2-c]pyridin-4-amine	HCID 18450710	—
촉매	Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)	HCID 24350	—
용매	1,4-Dioxane	HCID 31275	—
생성물	N-[4-amino-3-(4-amino-3-methoxyphenyl)thieno[3,2-c]pyridin-7-yl]-2-pyrrolidin-1-ylacetamide triacetate salt	HCID 18451403	—

반응 조건

온도	110 °C

반응 단계

A schlenck tube was charged with 3-(4-amino-3-methoxyphenyl)-7-iodothieno[3,2-c]pyridin-4-amine (199 mg, 0.5 mmol), 2-pyrrolidin-1-ylacetamide (0.6 mmol), copper(I) iodide (4.8 mg, 0.025 mmol), potassium phosphate (225 mg, 1.06 mmol). Evacuated under vacuum and back filled with nitrogen. trans-Cyclohexane-1,2-diamine (6.5 uL, 0.05 mmol) and dioxane (1 mL) was added. The reaction tube was sealed and heated at about 110° C. overnight. The solvent was removed and the crude product was purified by reverse phase preparative HPLC to give the title compound as the tri-acetate salt. LCMS (Conditions a): MH+=398.2, Rt=1.55 min. (154 mg, 45%)

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07737160B2
출처 데이터셋	uspto-grants-2010_06
ORD ID	ord-a1656f847d5b4166abc0cb76fd0c498c
출처 메모	uspto-grants-2010_06