Tetrahydrofuran → (2-Methyl-1H-benzimidazol-4-yl)methanol
반응식
[CH3:1][C:2]1[NH:6][C:5]2[CH:7]=[CH:8][CH:9]=[C:10]([C:11](OCC)=[O:12])[C:4]=2[N:3]=1.O1CCCC1.[AlH4-].[Li+].C(OCC)(=O)C>O>[CH3:1][C:2]1[NH:6][C:5]2[CH:7]=[CH:8][CH:9]=[C:10]([CH2:11][OH:12])[C:4]=2[N:3]=1참가 물질
6
실험 절차
(a-2) A cooled (0° C.) solution of 10 parts of ethyl 2-methyl-1H-benzimidazole-4-carboxylate in 45 parts of tetrahydrofuran was added dropwise to a suspension of 4 parts of lithium tetrahydroaluminate in 45 parts of tetrahydrofuran. Upon complete addition, the temperature was allowed to reach room temperature. After the addition of ethyl acetate and water, the reaction mixture was filtered over diatomaceous earth. The filtrate was evaporated, yielding 6.3 parts (79.4%) of 2-methyl-1H-benzimidazole-4-methanol as a residue (int. 66).
후처리
- additionUpon complete addition
- customto reach room temperature
- filtrationthe reaction mixture was filtered over diatomaceous earth
- customThe filtrate was evaporated
출처 및 근거
- ORD 기록
- ord-fdcb98520d294504a9287656ca2d82b5
- 출처 데이터셋
- uspto-grants-1989_08
- 특허 번호
- US04859684
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