2-Ethylhexanoyl chloride → Methyl 4-[5-(2-ethylhexanamido)indol-3-ylmethyl]-3methoxybenzoate
반응식
[CH2:1]([CH:3]([CH2:7][CH2:8][CH2:9][CH3:10])[C:4](Cl)=[O:5])[CH3:2].[NH2:11][C:12]1[CH:13]=[C:14]2[C:18](=[CH:19][CH:20]=1)[NH:17][CH:16]=[C:15]2[CH2:21][C:22]1[CH:31]=[CH:30][C:25]([C:26]([O:28][CH3:29])=[O:27])=[CH:24][C:23]=1[O:32][CH3:33]>>[CH2:1]([CH:3]([CH2:7][CH2:8][CH2:9][CH3:10])[C:4]([NH:11][C:12]1[CH:13]=[C:14]2[C:18](=[CH:19][CH:20]=1)[NH:17][CH:16]=[C:15]2[CH2:21][C:22]1[CH:31]=[CH:30][C:25]([C:26]([O:28][CH3:29])=[O:27])=[CH:24][C:23]=1[O:32][CH3:33])=[O:5])[CH3:2]참가 물질
3
실험 절차
Using a similar procedure to that described in Example 1, but starting from 2-ethylhexanoyl chloride and (A), there was obtained the title compound in 76% yield; partial NMR: 0.84(m,6H, 2×CH3), 1.24[m,6H, (CH2)3 ], 2.24(m,1H, CHCON), 10.78(d,1H, NH).
출처 및 근거
- ORD 기록
- ord-5c769417e4b7462d94a3db3d2f1db629
- 출처 데이터셋
- uspto-grants-1989_08