Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 3,3,3-Trifluoro-2-(trifluoromethyl)-1,2-propanediol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Water | HCID 962 | — |
| 반응물 | Methyl 3,3,3-trifluoro-2-hydroxy-2-trifluoromethylpropionate | HCID 9877912 | — |
| 반응물 | HCID 178418435 | HCID 178418435 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | 3,3,3-Trifluoro-2-(trifluoromethyl)-1,2-propanediol | HCID 11805677 | 96% |
반응 단계
With stirring, 100 g of methyl 2-hydroxy-3,3,3-trifluoro-2-trifluoromethylpropionate was added dropwise to a mixture of 25.0 g sodium boron hydride, 500 g water and 500 g diethyl ether. Stirring continued for 10 hours, after which hydrochloric acid was added to quench the reaction. The organic layer was separated, concentrated, and distilled, obtaining 83.9 g of 3,3,3-trifluoro-2-trifluoromethyl-1,2-propane diol (yield 96%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07485408B2 |
| 출처 데이터셋 | uspto-grants-2009_02 |
| ORD ID | ord-581c18f00d20498ebc21c1af0e00e8f8 |
| 출처 메모 | uspto-grants-2009_02 |