Ethyl 3-Hydroxybutyrate → ethyl (S)-4-azido-3-hydroxybutyrate

HRID 1723612노트

반응식

HRID 1723612 반응식
OC(C)CC(OCC)=O.[N:10]([CH2:13][CH:14]([OH:21])[CH2:15][C:16]([O:18][CH2:19][CH3:20])=[O:17])=[N+:11]=[N-:12]>>[N:10]([CH2:13][C@@H:14]([OH:21])[CH2:15][C:16]([O:18][CH2:19][CH3:20])=[O:17])=[N+:11]=[N-:12]

참가 물질

3

반응물 2

HCID 62572Ethyl 3-HydroxybutyrateHCID 14685344Ethyl 4-azido-3-hydroxybutyrate

생성물 1

HCID 10888398ethyl (S)-4-azido-3-hydroxybutyrate수율 80.2%

실험 절차

Instead of ethyl 3-hydroxybutyrate used in Example 1, ethyl 4-azido-3-hydroxybutyrate was used. The reaction was carried out for 1 hour and ethyl (S)-4-azido-3-hydroxybutyrate (80.2% e.e) was obtained at 83.5% conversion.

출처 및 근거

ORD 기록
ord-db7f65637b054d018429f55febfd6198
출처 데이터셋
uspto-grants-2009_02
특허 번호
US07485452B2

반응 노트

불러오는 중…