Methyl isothiocyanate → 1-(4-Dimethylaminocyclohexyl)-3-methyl-thiourea

HRID 1723624노트

반응식

[CH3:1][N:2]=[C:3]=[S:4].[CH3:5][N:6]([CH3:14])[C@H:7]1[CH2:12][CH2:11][C@H:10]([NH2:13])[CH2:9][CH2:8]1>>[CH3:5][N:6]([CH3:14])[CH:7]1[CH2:12][CH2:11][CH:10]([NH:13][C:3]([NH:2][CH3:1])=[S:4])[CH2:9][CH2:8]1

참가 물질

반응물 2

HCID 11167Methyl isothiocyanate

HCID 178484105HCID 178484105, 화합물

생성물 1

HCID 42216371-(4-Dimethylaminocyclohexyl)-3-methyl-thiourea

실험 절차

0.90 g of Methyl-isothiocyanate are added to a solution of 1.74 g of trans-4-dimethylamino-cyclohexanamine in 50 ml of EtAc. The mixture obtained is stirred at RT, solvent is evaporated and 1-(4-dimethylaminocyclohexyl)-3-methyl-thiourea is obtained.

후처리

customThe mixture obtained
customsolvent is evaporated

출처 및 근거

ORD 기록: ord-26d5dd4e7ab34ea3bd1bf925f10025a1
출처 데이터셋: uspto-grants-2009_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07485632B2

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