Dimethylformamide → HCID 67037586, 화합물
반응식
[CH:1]1([N:5]2[CH:9]=[C:8](C(=O)C)[N:7]=[C:6]2[CH3:13])[CH2:4][CH2:3][CH2:2]1.[CH3:14][C:15]([N:17]([CH3:19])[CH3:18])=O.CN([CH:23]=[O:24])C>>[CH3:18][N:17]([CH3:19])[CH:15]=[CH:14][C:23]([C:9]1[N:5]([CH:1]2[CH2:2][CH2:3][CH2:4]2)[C:6]([CH3:13])=[N:7][CH:8]=1)=[O:24]참가 물질
4
실험 절차
1-Cyclobutyl-2-methyl-4-acetylimidazole (Method 3; 2.52 g, 14.1 mmol) was dissolved in DMF.DMA (75 mL) and the mixture heated at reflux, under an atmosphere of nitrogen, for 54 hours. The reaction mixture was allowed to cool to ambient temperature the product crystallised. The solid product was collected by filtration, washed with DMF.DMA and then ether and dried under vacuum at 40° C. to give the title compound (1.55 g, 47%) as a pale brown crystalline solid. NMR: 1.72 (m, 2H), 2.28 (m, 2H), 2.39 (s, 3H), 2.64 (m, 2H), 2.95 (m, 6H), 5.22 (m, 1H), 5.50 (d, 1H), 7.39 (s, 1H), 7.51 (d, 1H).